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In addition, in our assay we use an N-terminal peptide of the recombinant nAngptl4 protein to measure LPL activity in the presence and absence of nAngptl4, allowing us to calculate Angptl4-sensitive lipase activity, and therefore LPL-mediated hydrolysis

doi: 10.3389/FMATS.2018.00019 186 van SeventerJ

While there may be similarities between these molecules based on one of these factors, the use of all three data points can be utilized to distinguish and differentiate biochemicals